Phospho-B-Myb (Thr494) Antibody - #AF8031
| 製品: | Phospho-B-Myb (Thr494) Antibody |
| カタログ: | AF8031 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-B-Myb (Thr494) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 79kDa; 79kD(Calculated). |
| ユニプロット: | P10244 |
| RRID: | AB_2840094 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8031, RRID:AB_2840094.
折りたたみ／展開
B-Myb; BMyB; MGC15600; MYB L2; Myb related protein B; Myb-like protein 2; Myb-related protein B; MybB; MYBB_HUMAN; MYBL 2; Mybl2; v myb avian myeloblastosis viral oncogene homolog like 2; v myb myeloblastosis viral oncogene homolog (avian) like 2; v myb myeloblastosis viral oncogene homolog like 2;
免疫原
- P10244 MYBB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQPSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMSTLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10244 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y15 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S20 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K93 | Sumoylation | Uniprot | |
| K104 | Sumoylation | Uniprot | |
| K134 | Sumoylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K197 | Sumoylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| K236 | Sumoylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| T396 | Phosphorylation | Uniprot | |
| T405 | Phosphorylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K447 | Ubiquitination | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| T465 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| T476 | Phosphorylation | Uniprot | |
| T486 | Phosphorylation | Uniprot | |
| T487 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T494 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K499 | Ubiquitination | Uniprot | |
| T505 | Phosphorylation | Uniprot | |
| K509 | Sumoylation | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| T520 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K523 | Ubiquitination | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| T538 | Phosphorylation | Uniprot | |
| K546 | Sumoylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S577 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K584 | Ubiquitination | Uniprot | |
| S585 | Phosphorylation | Uniprot | |
| K596 | Sumoylation | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| K639 | Sumoylation | Uniprot | |
| K639 | Ubiquitination | Uniprot | |
| K648 | Ubiquitination | Uniprot | |
| T693 | Phosphorylation | Uniprot | |
| R695 | Methylation | Uniprot |
研究背景
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
Nucleus.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
研究領域
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.