Phospho-RGS19 (Ser151) Antibody - #AF8274
| 製品: | Phospho-RGS19 (Ser151) Antibody |
| カタログ: | AF8274 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-RGS19 (Ser151) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 25kDa; 25kD(Calculated). |
| ユニプロット: | P49795 |
| RRID: | AB_2840336 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8274, RRID:AB_2840336.
折りたたみ／展開
G alpha interacting protein; G protein signalling regulator 19; G protein, alpha-interacting protein; G-alpha-interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; Regulator of G-protein signaling 19; RGS19; RGS19_HUMAN; RGSGAIP;
免疫原
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
- P49795 RGS19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49795 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S24 | Phosphorylation | P17252 (PRKCA) , P19784 (CSNK2A2) , P68400 (CSNK2A1) | Uniprot |
| S62 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| Y143 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| K153 | Ubiquitination | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| T201 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| Y202 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot |
研究背景
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Phosphorylated, mainly on serine residues.
Membrane>Lipid-anchor.
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Interacts with GIPC PDZ domain.
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