Phospho-LAB (Tyr136) Antibody - #AF8278

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製品: Phospho-LAB (Tyr136) Antibody
カタログ: AF8278
タンパク質の説明: Rabbit polyclonal antibody to Phospho-LAB (Tyr136)
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Dog
分子量: 26KD; 27kD(Calculated).
ユニプロット: Q9GZY6
RRID: AB_2840340

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(89%), Bovine(89%), Horse(100%), Sheep(89%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
Phospho-LAB (Tyr136) Antibody detects endogenous levels of LAB only when phosphorylated at Tyr136.
RRID:
AB_2840340
引用形式: Affinity Biosciences Cat# AF8278, RRID:AB_2840340.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

HSPC046; LAB; LAT2; Linker for activation of B cells; Linker for activation of B-cells; Linker for activation of T cells family member 2; Linker for activation of T cells transmembrane adaptor 2; Linker for activation of T-cells family member 2; Membrane associated adapter molecule; Membrane-associated adapter molecule; Non T cell activation linker; Non-T-cell activation linker; NTAL_HUMAN; WBSCR 5; Wbscr15; Williams Beuren syndrome chromosome region 15; Williams Beuren syndrome chromosome region 5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; WSCR5;

免疫原

免疫原:
Uniprot:

Q9GZY6(NTAL_HUMAN) >>Visit HPA database.

遺伝子(ID):
LAT2(7462)
発現特異性:
Q9GZY6 NTAL_HUMAN:

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

タンパク質配列:
MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Dog
100
Pig
89
Bovine
89
Sheep
89
Chicken
56
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9GZY6 基板として

Site PTM Type Enzyme
Y40 Phosphorylation
S44 Phosphorylation
S51 Phosphorylation
S55 Phosphorylation
T57 Phosphorylation
Y58 Phosphorylation
S59 Phosphorylation
K77 Ubiquitination
K79 Ubiquitination
Y84 Phosphorylation
S86 Phosphorylation
Y95 Phosphorylation P07948 (LYN)
K100 Ubiquitination
S102 Phosphorylation
S106 Phosphorylation
Y110 Phosphorylation P10721 (KIT) , P07948 (LYN)
Y118 Phosphorylation P10721 (KIT) , P07948 (LYN)
Y119 Phosphorylation P07948 (LYN)
K126 Ubiquitination
S135 Phosphorylation
Y136 Phosphorylation P07948 (LYN) , P43405 (SYK)
S167 Phosphorylation
S183 Phosphorylation
S190 Phosphorylation
Y193 Phosphorylation P43405 (SYK)
S196 Phosphorylation
S198 Phosphorylation
S205 Phosphorylation
S217 Phosphorylation
Y233 Phosphorylation P43405 (SYK)

研究背景

機能:

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

PTMs:

Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.

May be polyubiquitinated.

細胞の位置付け:

Cell membrane>Single-pass type III membrane protein.
Note: Present in lipid rafts.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

サブユニット構造:

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.

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