Phospho-DUSP16 (Ser446) Antibody - #AF8287
| 製品: | Phospho-DUSP16 (Ser446) Antibody |
| カタログ: | AF8287 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-DUSP16 (Ser446) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Rabbit, Chicken |
| 分子量: | 73kDa; 73kD(Calculated). |
| ユニプロット: | Q9BY84 |
| RRID: | AB_2840349 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8287, RRID:AB_2840349.
折りたたみ／展開
Dual specificity phosphatase 16; Dual specificity protein phosphatase 16; DUS16_HUMAN; DUSP 16; DUSP16; KIAA1700; MAP kinase phosphatase 7; MAPK phosphatase 7; Mitogen activated protein kinase phosphatase 7; Mitogen-activated protein kinase phosphatase 7; MKP 7; MKP-7; MKP7;
免疫原
- Q9BY84 DUS16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQSSQDVASLSSDCFLTVLLGKLEKSFNSVHLLAGGFAEFSRCFPGLCEGKSTLVPTCISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAASLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHRSGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVYSVRRRQKPSDRADSRRSWHEESPFEKQFKRRSCQMEFGESIMSENRSREELGKVGSQSSFSGSMEIIEVS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BY84 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S82 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S501 | Phosphorylation | Uniprot | |
| S604 | Phosphorylation | Uniprot | |
| S609 | Phosphorylation | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot |
研究背景
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.
(Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
Cytoplasm. Nucleus. Cytoplasmic vesicle.
Note: After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
Interacts with ARRB2.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
研究領域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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