Phospho-NDRG2 (Thr348) Antibody - #AF8292
| 製品: | Phospho-NDRG2 (Thr348) Antibody |
| カタログ: | AF8292 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-NDRG2 (Thr348) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 41kDa; 41kD(Calculated). |
| ユニプロット: | Q9UN36 |
| RRID: | AB_2840354 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8292, RRID:AB_2840354.
折りたたみ／展開
Antidepressant related protein ADRG123; Cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N myc downstream regulated gene 2; N myc downstream regulator 2; NDR1 related protein NDR2; NDRG 2; NDRG family member 2; NDRG1 related protein; NDRG2; NDRG2_HUMAN; Protein NDRG2; Protein Syld709613; SYLD; Syld709613 protein;
免疫原
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
- Q9UN36 NDRG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UN36 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| R247 | Methylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| Y309 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| T323 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | O00141 (SGK1) | Uniprot |
| S332 | Phosphorylation | P23443 (RPS6KB1) , O00141 (SGK1) , P31749 (AKT1) , Q15418 (RPS6KA1) | Uniprot |
| T334 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | O00141 (SGK1) | Uniprot |
| T348 | Phosphorylation | O00141 (SGK1) , P31749 (AKT1) | Uniprot |
| S350 | Phosphorylation | Q15418 (RPS6KA1) , P23443 (RPS6KB1) | Uniprot |
| S352 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| T357 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| T366 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot |
研究背景
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Cytoplasm. Cytoplasm>Perinuclear region. Cell projection>Growth cone.
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
Interacts with CTNNB1.
Belongs to the NDRG family.
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