Phospho-TAB1 (Ser438) Antibody - #AF8324
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8324, RRID:AB_2840386.
折りたたみ／展開
2310012M03Rik; 3'-Tab1; MAP3K7IP 1; MAP3K7IP1; MGC57664; Mitogen activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB 1; TAB1; TAB1_HUMAN; TAK1 binding protein 1; TAK1-binding protein 1; TGF beta activated kinase 1 binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; Transforming growth factor beta activated kinase binding protein 1;
免疫原
- Q15750 TAB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15750 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| Y179 | Phosphorylation | Uniprot | |
| T185 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| S395 | O-Glycosylation | Uniprot | |
| S423 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| T431 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S438 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| T442 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | O43318 (MAP3K7) , Q16539 (MAPK14) | Uniprot |
| S453 | Phosphorylation | O43318 (MAP3K7) , Q16539 (MAPK14) | Uniprot |
| S456 | Phosphorylation | Q16539 (MAPK14) , O43318 (MAP3K7) | Uniprot |
| S457 | Phosphorylation | Q16539 (MAPK14) , O43318 (MAP3K7) | Uniprot |
| S469 | Phosphorylation | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| Y488 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot |
研究背景
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
Ubiquitous.
Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.
研究領域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Toll-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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