Phospho-ETV6 / Tel (Ser257) Antibody - #AF8325
| 製品: | Phospho-ETV6 / Tel (Ser257) Antibody |
| カタログ: | AF8325 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-ETV6 / Tel (Ser257) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 53 KD; 53kD(Calculated). |
| ユニプロット: | P41212 |
| RRID: | AB_2840387 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8325, RRID:AB_2840387.
折りたたみ／展開
ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6;
免疫原
- P41212 ETV6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41212 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| K11 | Acetylation | Uniprot | |
| K11 | Sumoylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| Y17 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S26 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| K99 | Sumoylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| T161 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S182 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| T187 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| S238 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Q16539 (MAPK14) , P27361 (MAPK3) | Uniprot |
| S271 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K302 | Acetylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y314 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| Y401 | Phosphorylation | Uniprot | |
| Y402 | Phosphorylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| K421 | Sumoylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot |
研究背景
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.
Nucleus.
Ubiquitous.
Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9.
Belongs to the ETS family.
研究領域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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