Phospho-PFKFB2 (Ser466) Antibody - #AF8346
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8346, RRID:AB_2840408.
折りたたみ／展開
6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3; 6-bisphosphatase; 6-P2ase 3; 6-P2ASE brain/placenta-type isozyme; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme; 6PF 2-K/Fru 2,6 P2ase 3; 6PF-2-K/Fru-2; F263_HUMAN; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase; Fructose-2; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase; iPFK 2; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY REN 56; Renal carcinoma antigen NY-REN-56; uPFK 2;
免疫原
- O60825 F262_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60825 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K298 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| T458 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | P23443 (RPS6KB1) , Q13131 (PRKAA1) , P31749 (AKT1) , P17612 (PRKACA) , P51812 (RPS6KA3) , P54646 (PRKAA2) | Uniprot |
| T468 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| Y482 | Phosphorylation | Uniprot | |
| S483 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S486 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot |
研究背景
Synthesis and degradation of fructose 2,6-bisphosphate.
Phosphorylation by AMPK stimulates activity.
Heart.
Homodimer.
In the C-terminal section; belongs to the phosphoglycerate mutase family.
研究領域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
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