Phospho-ROR2 (Ser449) Antibody - #AF8451
| 製品: | Phospho-ROR2 (Ser449) Antibody |
| カタログ: | AF8451 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-ROR2 (Ser449) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 105kDa; 105kD(Calculated). |
| ユニプロット: | Q01974 |
| RRID: | AB_2840506 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8451, RRID:AB_2840506.
折りたたみ／展開
BDB; BDB1; Brachydactyly type B; EC 2.7.10.1; MGC163394; Neurotrophic tyrosine kinase; Neurotrophic tyrosine kinase, receptor related 2; NTRKR2; Receptor tyrosine kinase-like orphan receptor 2; receptor-related 2; ROR2; ROR2_HUMAN; Tyrosine protein kinase transmembrane receptor ROR2; Tyrosine-protein kinase transmembrane receptor Ror2;
免疫原
- Q01974 ROR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q01974 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K97 | Ubiquitination | Uniprot | |
| T157 | O-Glycosylation | Uniprot | |
| T438 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K507 | Ubiquitination | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| Y555 | Phosphorylation | Uniprot | |
| Y624 | Phosphorylation | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| Y645 | Phosphorylation | Uniprot | |
| Y646 | Phosphorylation | Uniprot | |
| K647 | Ubiquitination | Uniprot | |
| Y666 | Phosphorylation | Uniprot | |
| Y755 | Phosphorylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| S782 | Phosphorylation | Uniprot | |
| K792 | Ubiquitination | Uniprot | |
| Y824 | Phosphorylation | Uniprot | |
| S864 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| Y873 | Phosphorylation | Uniprot |
研究背景
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Cell membrane>Single-pass type I membrane protein.
Homodimer; promotes osteogenesis. Binds YWHAB. Interacts with WTIP (By similarity).
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
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