Phospho-BCL-3 (Ser402) Antibody - #AF8466
| 製品: | Phospho-BCL-3 (Ser402) Antibody |
| カタログ: | AF8466 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-BCL-3 (Ser402) |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Horse |
| 分子量: | 50-60kD; 48kD(Calculated). |
| ユニプロット: | P20749 |
| RRID: | AB_2840520 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8466, RRID:AB_2840520.
折りたたみ／展開
B cell CLL/lymphoma 3; B cell leukemia/lymphoma 3; B cell lymphoma 3 encoded protein; B-cell lymphoma 3 protein; Bcl 3; BCL 4; BCL-3; Bcl3; BCL3_HUMAN; BCL4; Chronic lymphatic leukemia protein; D19S37; Protein Bcl 3; Proto-oncogene BCL3;
免疫原
- P20749 BCL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P20749 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K21 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| K338 | Methylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S402 | Phosphorylation | P49840 (GSK3A) | Uniprot |
| S406 | Phosphorylation | P49840 (GSK3A) | Uniprot |
| S448 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot |
研究背景
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).
Activated by phosphorylation.
Nucleus. Cytoplasm. Cytoplasm>Perinuclear region.
Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity).
研究領域
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
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