Phospho-PDE3A (Ser312) Antibody - #AF8501
| 製品: | Phospho-PDE3A (Ser312) Antibody |
| カタログ: | AF8501 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-PDE3A (Ser312) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Horse, Rabbit, Chicken |
| 分子量: | 125 kDa; 125kD(Calculated). |
| ユニプロット: | Q14432 |
| RRID: | AB_2840555 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8501, RRID:AB_2840555.
折りたたみ／展開
5''-cyclic phosphodiesterase A; cAMP phosphodiesterase myocardial cGMP inhibited; CGI PDE; CGI PDE A; CGI-PDE A; cGMP inhibited 3' 5' cyclic phosphodiesterase A; cGMP-inhibited 3''; Cyclic GMP inhibited phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; Human cGMP inhibited cAMP phosphodiesterase mRNA; PDE 3A; Pde3a; PDE3A_HUMAN; Phosphodiesterase 3A; Phosphodiesterase 3A cGMP inhibited;
免疫原
- Q14432 PDE3A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14432 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K287 | Ubiquitination | Uniprot | |
| S292 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S293 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S294 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| T399 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| S428 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S438 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S439 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| T442 | Phosphorylation | Uniprot | |
| T443 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | Uniprot | |
| T445 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K467 | Ubiquitination | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| S492 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T494 | Phosphorylation | Uniprot | |
| Y497 | Phosphorylation | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| K518 | Ubiquitination | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| T533 | Phosphorylation | Uniprot | |
| K541 | Ubiquitination | Uniprot | |
| S550 | Phosphorylation | Uniprot | |
| T553 | Phosphorylation | Uniprot | |
| T554 | Phosphorylation | Uniprot | |
| K556 | Ubiquitination | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| S561 | Phosphorylation | Uniprot | |
| T568 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| S575 | Phosphorylation | Uniprot | |
| T580 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| T615 | Phosphorylation | Uniprot | |
| T618 | Phosphorylation | Uniprot | |
| T643 | Phosphorylation | Uniprot | |
| S654 | Phosphorylation | Uniprot | |
| K729 | Ubiquitination | Uniprot | |
| K912 | Ubiquitination | Uniprot | |
| K919 | Ubiquitination | Uniprot | |
| K923 | Ubiquitination | Uniprot | |
| K947 | Ubiquitination | Uniprot | |
| K956 | Ubiquitination | Uniprot | |
| K1088 | Ubiquitination | Uniprot | |
| S1103 | Phosphorylation | Uniprot | |
| T1107 | Phosphorylation | Uniprot | |
| K1120 | Ubiquitination | Uniprot | |
| T1136 | Phosphorylation | Uniprot |
研究背景
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Membrane>Multi-pass membrane protein.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Endocrine system > Renin secretion.
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