Phospho-SYN2 (Ser425) Antibody - #AF8514
| 製品: | Phospho-SYN2 (Ser425) Antibody |
| カタログ: | AF8514 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-SYN2 (Ser425) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 78 kDa; 63kD(Calculated). |
| ユニプロット: | Q92777 |
| RRID: | AB_2840568 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8514, RRID:AB_2840568.
折りたたみ／展開
SYN 2; SYN II; SYN IIa; SYN IIb; SYN2; Synapsin 2; Synapsin II isoform IIa; Synapsin II isoform IIb; Synapsin2; SynapsinII; SYNII; SYNIIa; SYNIIb;
免疫原
- Q92777 SYN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPPGPGAASASAAPPTASPGPERRPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVDEPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKDPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPPGPSLPPSSSSSSSSSSSAPQRPGGPTTHGDAPSSSSSLAEAQPPLAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92777 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| T421 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| T432 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| S575 | Phosphorylation | Uniprot |
研究背景
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).
Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).
Cell junction>Synapse.
Central and peripheral nervous systems.
Interacts with CAPON.
The A region binds phospholipids with a preference for negatively charged species.
Belongs to the synapsin family.
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