IL28RA Antibody - #DF10108
| 製品: | IL28RA Antibody |
| カタログ: | DF10108 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL28RA |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Rabbit, Dog |
| 分子量: | 58 kDa; 58kD(Calculated). |
| ユニプロット: | Q8IU57 |
| RRID: | AB_2840688 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10108, RRID:AB_2840688.
折りたたみ／展開
Class II cytokine receptor CRF2/12; CRF2-12; CRF2/12; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; IFN lambda R1; IFN-lambda receptor 1; IFNLR; IFNLR1; IL-28 receptor subunit alpha; il-28r1; IL28R alpha; IL28RA; Interferon lambda receptor; Interferon lambda receptor 1; interleukin 28 alpha receptor; interleukin 28 receptor A; Interleukin 28 receptor alpha chain; interleukin 28 receptor, alpha (interferon, lambda receptor); Interleukin 28 receptor, alpha; interleukin or cytokine receptor 2; Interleukin-28 receptor subunit alpha; LICR2; Likely interleukin or cytokine receptor 2;
免疫原
- Q8IU57 INLR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IU57 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N29 | N-Glycosylation | Uniprot | |
| N36 | N-Glycosylation | Uniprot | |
| N142 | N-Glycosylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| Y209 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| Y517 | Phosphorylation | Uniprot |
研究背景
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Membrane>Single-pass type I membrane protein.
Widely expressed.
Heterodimer with IL10RB.
Belongs to the type II cytokine receptor family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
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