IL31R Antibody - #DF10114
| 製品: | IL31R Antibody |
| カタログ: | DF10114 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL31R |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Sheep, Dog |
| 分子量: | 83 kDa; 83kD(Calculated). |
| ユニプロット: | Q8NI17 |
| RRID: | AB_2840694 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10114, RRID:AB_2840694.
折りたたみ／展開
Class I cytokine receptor; CRL 3; CRL; CRL3; Cytokine receptor like 3; Cytokine receptor-like 3; GLM R; GLM-R; GLMR; Gp130 like monocyte receptor; GP130 like receptor; Gp130-like monocyte receptor; Gp130-like receptor; GPL; HGLM R; HGLM-R; HGLMR; IL 31 receptor subunit alpha; IL 31R subunit alpha; IL 31RA; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; IL31 receptor subunit alpha; IL31R subunit alpha; IL31R_HUMAN; IL31RA; Interleukin 31 receptor A; interleukin 31 receptor subunit alpha; Interleukin-31 receptor subunit alpha; MGC125346; PLCA 2; PLCA2; PRO21384; Soluble type I cytokine receptor CRL3; ZcytoR17;
免疫原
Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).
- Q8NI17 IL31R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMWTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NI17 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T122 | Phosphorylation | Uniprot | |
| Y460 | Phosphorylation | Uniprot | |
| S483 | Phosphorylation | Uniprot | |
| Y708 | Phosphorylation | Uniprot |
研究背景
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).
N-glycosylated.
Cell membrane>Single-pass type I membrane protein. Cell junction>Synapse>Presynaptic cell membrane. Cell projection>Axon.
Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts. Detected in all of the myelomonocytic lineage. Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients.
Heterodimer with OSMR. Interacts with JAK1 and STAT3.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
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