CCNB3 Antibody - #DF10120
| 製品: | CCNB3 Antibody |
| カタログ: | DF10120 |
| タンパク質の説明: | Rabbit polyclonal antibody to CCNB3 |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 分子量: | 158 kDa; 158kD(Calculated). |
| ユニプロット: | Q8WWL7 |
| RRID: | AB_2840700 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10120, RRID:AB_2840700.
折りたたみ／展開
CCNB 3; CYCB3; G2/mitotic specific cyclin B3;
免疫原
Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.
- Q8WWL7 CCNB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKRSAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL
PTMs - Q8WWL7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K87 | Acetylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| K364 | Acetylation | Uniprot | |
| K416 | Acetylation | Uniprot | |
| T497 | Phosphorylation | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| Y618 | Phosphorylation | Uniprot | |
| K633 | Acetylation | Uniprot | |
| K643 | Acetylation | Uniprot | |
| K656 | Acetylation | Uniprot | |
| S753 | Phosphorylation | Uniprot | |
| T754 | Phosphorylation | Uniprot | |
| S954 | Phosphorylation | Uniprot | |
| S996 | Phosphorylation | Uniprot | |
| S1000 | Phosphorylation | Uniprot | |
| T1002 | Phosphorylation | Uniprot | |
| T1038 | Phosphorylation | Uniprot | |
| S1089 | Phosphorylation | Uniprot | |
| S1120 | Phosphorylation | Uniprot | |
| S1174 | Phosphorylation | Uniprot | |
| T1178 | Phosphorylation | Uniprot | |
| Y1319 | Phosphorylation | Uniprot | |
| S1331 | Phosphorylation | Uniprot | |
| S1333 | Phosphorylation | Uniprot |
研究背景
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.
Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.
Nucleus.
Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.
Interacts with CDK2 kinase.
The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Belongs to the cyclin family. Cyclin AB subfamily.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
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