IL28A Antibody - #DF10159
| 製品: | IL28A Antibody |
| カタログ: | DF10159 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL28A |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 分子量: | 22 kDa; 22kD(Calculated). |
| ユニプロット: | Q8IZJ0 |
| RRID: | AB_2840738 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10159, RRID:AB_2840738.
折りたたみ／展開
Cytokine ZCYTO20; IFN-lambda-2; IFNL2; IL-28A; IL28A; IL28A_HUMAN; Interferon lambda 2; Interferon lambda-2; interleukin 28A (interferon, lambda 2); Interleukin 28A; Interleukin-28A; ZCYTO20;
免疫原
- Q8IZJ0 IFNL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLDMTGDCTPVLVLMAAVLTVTGAVPVARLHGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV
PTMs - Q8IZJ0 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T146 | Phosphorylation | Uniprot |
研究背景
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Secreted.
Belongs to the lambda interferon family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
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