HTR3B Antibody - #DF10195
| 製品: | HTR3B Antibody |
| カタログ: | DF10195 |
| タンパク質の説明: | Rabbit polyclonal antibody to HTR3B |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 50 kDa; 50kD(Calculated). |
| ユニプロット: | O95264 |
| RRID: | AB_2840774 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10195, RRID:AB_2840774.
折りたたみ／展開
5 HT3 B; 5 HT3B; 5 HTR3B; 5 hydroxytryptamine 3 receptor B subunit; 5 hydroxytryptamine receptor 3B; 5 hydroxytryptamine serotonin receptor 3B; 5-HT3-B; 5-HT3B; 5-hydroxytryptamine receptor 3B; 5HT3B_HUMAN; 5HTR3B; Htr3b; Serotonin gated ion channel subunit; Serotonin receptor 3B;
免疫原
Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
- O95264 5HT3B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
PTMs - O95264 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K37 | Ubiquitination | Uniprot | |
| N52 | N-Glycosylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| N96 | N-Glycosylation | Uniprot | |
| N138 | N-Glycosylation | Uniprot | |
| N168 | N-Glycosylation | Uniprot | |
| N203 | N-Glycosylation | Uniprot | |
| R352 | Methylation | Uniprot |
研究背景
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
N-glycosylation required for membrane localization.
Cell membrane>Multi-pass membrane protein.
Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
研究領域
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Sensory system > Taste transduction.
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