TAF6L Antibody - #AF0691
| 製品: | TAF6L Antibody |
| カタログ: | AF0691 |
| タンパク質の説明: | Rabbit polyclonal antibody to TAF6L |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 68kDa; 68kD(Calculated). |
| ユニプロット: | Q9Y6J9 |
| RRID: | AB_2834363 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0691, RRID:AB_2834363.
折りたたみ／展開
CBP associated factor associated factor 65 kDa subunit 6L; PAF65 alpha; PAF65A; PCAF associated factor 65 alpha; TAF6 like RNA polymerase II p300/CBP associated factor associated factor 65 kDa subunit 6L; TAF6-like RNA polymerase II p300;
免疫原
- Q9Y6J9 TAF6L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVALQDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADPVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPNRGGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFGSGLPLPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPDSVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPGTGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPMIGRTSRPARRWALSDYSLYLPL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y6J9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| Y42 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| Y333 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| T458 | Phosphorylation | Uniprot | |
| T464 | Phosphorylation | Uniprot | |
| S481 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| K549 | Ubiquitination | Uniprot | |
| R555 | Methylation | Uniprot | |
| R561 | Methylation | Uniprot | |
| R567 | Methylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| R593 | Methylation | Uniprot | |
| K597 | Ubiquitination | Uniprot |
研究背景
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity).
Nucleus.
The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
Belongs to the TAF6 family.
研究領域
· Genetic Information Processing > Transcription > Basal transcription factors.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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