TA2R Antibody - #DF10271
| 製品: | TA2R Antibody |
| カタログ: | DF10271 |
| タンパク質の説明: | Rabbit polyclonal antibody to TA2R |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 37 kDa; 37kD(Calculated). |
| ユニプロット: | P21731 |
| RRID: | AB_2840849 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10271, RRID:AB_2840849.
折りたたみ／展開
BDPLT13; Prostanoid TP receptor; TA2R_HUMAN; Tbxa2r; Thromboxane A2 receptor; TP receptor; TXA2 R; TXA2-R; TXA2R;
免疫原
- P21731 TA2R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
PTMs - P21731 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S118 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S329 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S331 | Phosphorylation | P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| T337 | Phosphorylation | P17252 (PRKCA) | Uniprot |
研究背景
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Cell membrane>Multi-pass membrane protein.
Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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