TAS2R46 Antibody - #DF10303
| 製品: | TAS2R46 Antibody |
| カタログ: | DF10303 |
| タンパク質の説明: | Rabbit polyclonal antibody to TAS2R46 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 36 kDa; 36kD(Calculated). |
| ユニプロット: | P59540 |
| RRID: | AB_2840881 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10303, RRID:AB_2840881.
免疫原
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.
- P59540 T2R46_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS
PTMs - P59540 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T191 | Phosphorylation | Uniprot | |
| T289 | Phosphorylation | Uniprot |
研究背景
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Membrane>Multi-pass membrane protein. Cell projection>Cilium membrane.
Note: In airway epithelial cells, localizes to motile cilia.
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed on ciliated airway epithelium.
Belongs to the G-protein coupled receptor T2R family.
研究領域
· Organismal Systems > Sensory system > Taste transduction.
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