TXNIP Antibody - #DF7506
(4)
(2)
| 製品: | TXNIP Antibody |
| カタログ: | DF7506 |
| タンパク質の説明: | Rabbit polyclonal antibody to TXNIP |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 50 kDa; 44kD(Calculated). |
| ユニプロット: | Q9H3M7 |
| RRID: | AB_2841006 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7506, RRID:AB_2841006.
折りたたみ／展開
EST01027; HHCPA78; THIF; Thioredoxin binding protein 2; Thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; TXNIP; TXNIP_HUMAN; Upregulated by 1,25 dihydroxyvitamin D 3; VDUP1; Vitamin D3 up-regulated protein 1;
免疫原
- Q9H3M7 TXNIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H3M7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Sumoylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K19 | Sumoylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K100 | Sumoylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K115 | Sumoylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K117 | Sumoylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K140 | Sumoylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K163 | Sumoylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K167 | Sumoylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K212 | Sumoylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K228 | Sumoylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K233 | Sumoylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| K287 | Sumoylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| T348 | Phosphorylation | Uniprot | |
| T349 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| Y378 | Phosphorylation | Uniprot | |
| T379 | Phosphorylation | Uniprot |
研究背景
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
Cytoplasm.
Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.
Belongs to the arrestin family.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
参考文献
Application: IHC Species: Mouse Sample:
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.