DVL1 Antibody - #DF7515
| 製品: | DVL1 Antibody |
| カタログ: | DF7515 |
| タンパク質の説明: | Rabbit polyclonal antibody to DVL1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 75 kDa; 75kD(Calculated). |
| ユニプロット: | O14640 |
| RRID: | AB_2841014 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7515, RRID:AB_2841014.
折りたたみ／展開
Dishevelled 1; dishevelled 1 like; Dishevelled; Dishevelled dsh homolog 1; Dishevelled-1; Dishevelled1; DSH homolog 1; Dvl 1; Dvl; Dvl1; DVL1_HUMAN; DVL1L1; MGC54245; Segment polarity protein dishevelled homolog DVL 1; segment polarity protein dishevelled homolog DVL 1 like; Segment polarity protein dishevelled homolog DVL-1; Segment polarity protein dishevelled homolog DVL1;
免疫原
- O14640 DVL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14640 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| Ubiquitination | Uniprot | ||
| Y8 | Phosphorylation | Uniprot | |
| Y17 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S79 | Phosphorylation | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| T96 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | P49674 (CSNK1E) | Uniprot |
| S142 | Phosphorylation | P49674 (CSNK1E) | Uniprot |
| S188 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| T348 | Phosphorylation | Uniprot | |
| S390 | Phosphorylation | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| K469 | Ubiquitination | Uniprot | |
| S600 | Phosphorylation | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| S604 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| R626 | Methylation | Uniprot | |
| Y651 | Phosphorylation | Uniprot | |
| T674 | Phosphorylation | Uniprot | |
| S676 | Phosphorylation | Uniprot | |
| S679 | Phosphorylation | Uniprot |
研究背景
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytosol. Cytoplasmic vesicle.
Note: Localizes at the cell membrane upon interaction with frizzled family members.
Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts (via PDZ domain) with VANGL1 and VANGL2 (via C-terminus). Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Interacts (via PDZ domain) with TMEM88. Interacts with DCDC2. Interacts with FOXK2. Interacts with PKD1 (via extracellular domain). Interacts (via PDZ domain) with CCDC88C/DAPLE; competes with CCDC88C for binding to frizzled receptor FZD7 and dissociates from CCDC88C following initiation of non-canonical Wnt signaling when CCDC88C displaces DVL1 from ligand-activated FZD7.
The DIX domain promotes homooligomerization.
The DEP domain mediates interaction with the cell membrane.
Belongs to the DSH family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Breast cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
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