ASIP Antibody - #DF7612
| 製品: | ASIP Antibody |
| カタログ: | DF7612 |
| タンパク質の説明: | Rabbit polyclonal antibody to ASIP |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Bovine, Horse, Sheep, Dog |
| 分子量: | 14 kDa; 15kD(Calculated). |
| ユニプロット: | P42127 |
| RRID: | AB_2841101 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7612, RRID:AB_2841101.
折りたたみ／展開
agouti signaling protein; Agouti switch protein; AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9;
免疫原
Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
- P42127 ASIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42127 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S35 | Phosphorylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T96 | Phosphorylation | Uniprot |
研究背景
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Secreted.
Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
研究領域
· Organismal Systems > Endocrine system > Melanogenesis.
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