CYTH3 Antibody - #DF7653
| 製品: | CYTH3 Antibody |
| カタログ: | DF7653 |
| タンパク質の説明: | Rabbit polyclonal antibody to CYTH3 |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Dog, Chicken |
| 分子量: | 46 kDa; 46kD(Calculated). |
| ユニプロット: | O43739 |
| RRID: | AB_2841129 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7653, RRID:AB_2841129.
折りたたみ／展開
CYTH3; ARF nucleotide-binding site opener 3; ARNO3; ARNO3 protein; CYH3_HUMAN; Cyth3; Cytohesin-3; General receptor of phosphoinositides 1; Grp1; PH; PH, SEC7 and coiled-coil domain-containing protein 3; Protein ARNO3; PSCD3; SEC7 and coiled-coil domain-containing protein 3; SEC7 homolog C; Sec7-3; Sec7c;
免疫原
- O43739 CYH3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43739 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K32 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| Y359 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| Y386 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot |
研究背景
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity).
Cytoplasm>Cytosol. Cell membrane>Peripheral membrane protein. Cell junction>Adherens junction. Cell junction>Tight junction.
Note: Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Almost absent from liver, thymus and peripheral blood lymphocytes.
Interacts with GRASP (By similarity). Interacts with ARF6. Interacts with FRMD4A (By similarity). Interacts with FRMD4B (By similarity).
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
Autoinhibited by its C-terminal basic region.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
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