PPP1R1A Antibody - #DF7662
| 製品: | PPP1R1A Antibody |
| カタログ: | DF7662 |
| タンパク質の説明: | Rabbit polyclonal antibody to PPP1R1A |
| アプリケーション: | WB |
| 反応性: | Human, Monkey |
| 予測: | Dog |
| 分子量: | 27 kDa; 19kD(Calculated). |
| ユニプロット: | Q13522 |
| RRID: | AB_2841136 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7662, RRID:AB_2841136.
折りたたみ／展開
I 1; I-1; I1; Inhibitor 1; IPP 1; IPP-1; IPP1; Ppp1r1a; PPR1A_HUMAN; Protein phosphatase 1 regulatory (inhibitor) subunit 1A; Protein phosphatase 1 regulatory subunit 1A; Protein phosphatase inhibitor 1;
免疫原
- Q13522 PPR1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13522 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T35 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S46 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | P17612 (PRKACA) , P27361 (MAPK3) , Q00535 (CDK5) , P17252 (PRKCA) | Uniprot |
| T75 | Phosphorylation | P17252 (PRKCA) , P17612 (PRKACA) | Uniprot |
| T78 | Phosphorylation | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot |
研究背景
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Phosphorylation of Thr-35 is required for activity.
Interacts with PPP1R15A.
Belongs to the protein phosphatase inhibitor 1 family.
研究領域
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Nervous system > Long-term potentiation.
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