CHGA Antibody - #DF7672
| 製品: | CHGA Antibody |
| カタログ: | DF7672 |
| タンパク質の説明: | Rabbit polyclonal antibody to CHGA |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit |
| 分子量: | 50 kDa; 51kD(Calculated). |
| ユニプロット: | P10645 |
| RRID: | AB_2841144 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7672, RRID:AB_2841144.
折りたたみ／展開
beta Granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; CHG A; Chga; chromofungin; Chromogranin A; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; CMGA_HUMAN; ER-37; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; Secretory protein I; SP I; SP-I; SP1; SPI; Vasostatin; Vasostatin I; Vasostatin II;
免疫原
- P10645 CMGA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10645 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S53 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| Y381 | Phosphorylation | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot |
研究背景
Strongly inhibits glucose induced insulin release from the pancreas.
Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosaand. Can induce mast cell migration, degranulation and production of cytokines and chemokines. Acts as a potent scavenger of free radicals in vitro. May play a role in the regulation of cardiac function and blood pressure.
Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Sulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans.
Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity. Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides.
Secreted. Cytoplasmic vesicle>Secretory vesicle.
Note: Pyroglutaminated serpinin localizes to secretory vesicle.
Cytoplasmic vesicle>Secretory vesicle. Cytoplasmic vesicle>Secretory vesicle>Neuronal dense core vesicle. Secreted.
Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules.
GE-25 is found in the brain.
Interacts with SCG3.
Belongs to the chromogranin/secretogranin protein family.
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