GFRA4 Antibody - #AF0809

(2)  
製品: GFRA4 Antibody
カタログ: AF0809
タンパク質の説明: Rabbit polyclonal antibody to GFRA4
アプリケーション: WB IF/ICC
反応性: Human
分子量: 30kDa; 32kD(Calculated).
ユニプロット: Q9GZZ7
RRID: AB_2834399

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
GFRA4 Antibody detects endogenous levels of total GFRA4.
RRID:
AB_2834399
引用形式: Affinity Biosciences Cat# AF0809, RRID:AB_2834399.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107; Persephin receptor;

免疫原

免疫原:
Uniprot:

Q9GZZ7(GFRA4_HUMAN) >>Visit HPA database.

遺伝子(ID):
GFRA4(64096)
発現特異性:
Q9GZZ7 GFRA4_HUMAN:

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

タンパク質の説明:
GFRA4 Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.
タンパク質配列:
MVRCLGPALLLLLLLGSASSVGGNRCVDAAEACTADARCQRLRSEYVAQCLGRAAQGGCPRARCRRALRRFFARGPPALTHALLFCPCAGPACAERRRQTFVPSCAFSGPGPAPPSCLEPLNFCERSRVCRCARAAAGPWRGWGRGLSPAHRPPAAQASPPGLSGLVHPSAQRPRRLPAGPGRPLPARLRGPRGVPAGTAVTPNYVDNVSARVAPWCDCGASGNRREDCEAFRGLFTRNRCLDGAIQAFASGWPPVLLDQLNPQGDPEHSLLQVSSTGRALERRSLLSILPVLALPALL

研究背景

機能:

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

細胞の位置付け:

Cell membrane>Lipid-anchor.

Cell membrane>Lipid-anchor.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

サブユニット構造:

Interacts with SORL1.

タンパク質ファミリー:

Belongs to the GDNFR family.

Restrictive clause

 

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