Amylin Antibody - #DF7715
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7715, RRID:AB_2841184.
折りたたみ／展開
Amylin; DAP; Diabetes associated peptide; Diabetes-associated peptide; IAP; IAPP; IAPP_HUMAN; Insulinoma amyloid peptide; Islet amyloid polypeptide (diabetes associated peptide; amylin); Islet amyloid polypeptide;
免疫原
- P10997 IAPP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10997 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T23 | Phosphorylation | Uniprot |
研究背景
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Amyloid fibrils are degraded by IDE.
Secreted.
Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.
The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.
Belongs to the calcitonin family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young.
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