FATP1 Antibody - #DF7716
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(4)
| 製品: | FATP1 Antibody |
| カタログ: | DF7716 |
| タンパク質の説明: | Rabbit polyclonal antibody to FATP1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 65 kDa; 71kD(Calculated). |
| ユニプロット: | Q6PCB7 |
| RRID: | AB_2841185 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7716, RRID:AB_2841185.
折りたたみ／展開
ACSVL5; FATP 1; FATP; FATP1; Fatty acid transport protein 1; FLJ00336; Long chain fatty acid transport protein 1; MGC71751; SLC27A1; Solute carrier family 27 (fatty acid transporter) member 1; Solute carrier family 27 member 1;
免疫原
Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
- Q6PCB7 S27A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6PCB7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K202 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K238 | Acetylation | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| Y248 | Phosphorylation | Uniprot | |
| Y266 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| K474 | Ubiquitination | Uniprot | |
| K475 | Ubiquitination | Uniprot | |
| Y501 | Phosphorylation | Uniprot |
研究背景
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity).
Cell membrane>Single-pass membrane protein. Endomembrane system>Single-pass membrane protein. Cytoplasm.
Note: Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes.
Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
Self-associates. May function as a homodimer (By similarity). Interacts with EPRS1; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids.
Belongs to the ATP-dependent AMP-binding enzyme family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
参考文献
Application: WB Species: mouse Sample: placenta
Application: WB Species: mouse Sample: myocardial
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