OAS1 Antibody - #DF7760
| 製品: | OAS1 Antibody |
| カタログ: | DF7760 |
| タンパク質の説明: | Rabbit polyclonal antibody to OAS1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 46 kDa; 46kD(Calculated). |
| ユニプロット: | P00973 |
| RRID: | AB_2841226 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7760, RRID:AB_2841226.
折りたたみ／展開
(2 5')oligo(A) synthetase 1; (2-5'')oligo(A) synthase 1; 2 5 Oligoadenylate Synthetase 1; 2 5' oligo A synthase 1; 2 5' oligo A synthetase 1; 2 5A synthase 1; 2 5A synthetase 1; 2' 5' oligo A synthetase 1; 2' 5' oligoadenylate synthetase 1 40/46kDa; 2' 5' oligoadenylate synthetase 1; 2' 5' oligoisoadenylate synthetase 1; 2''-5''-oligoadenylate synthase 1; 2'5' oligo A synthetase 1; 2'5' oligoadenylate synthetase 1; 2'5' oligoisoadenylate synthetase 1; 2-5A synthase 1; E18/E16; IFI 4; IFI4; OAS 1; OAS1; OAS1_HUMAN; OIAS; OIASI; p46/p42 OAS;
免疫原
- P00973 OAS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL
PTMs - P00973 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K10 | Ubiquitination | Uniprot | |
| K42 | Acetylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| Y271 | Phosphorylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| Y362 | Phosphorylation | Uniprot | |
| Y367 | Phosphorylation | Uniprot |
研究背景
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted.
Note: Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Monomer. Homotetramer.
Belongs to the 2-5A synthase family.
研究領域
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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