SYNJ2 Antibody - #DF7795
| 製品: | SYNJ2 Antibody |
| カタログ: | DF7795 |
| タンパク質の説明: | Rabbit polyclonal antibody to SYNJ2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 140 kDa; 166kD(Calculated). |
| ユニプロット: | O15056 |
| RRID: | AB_2841252 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7795, RRID:AB_2841252.
折りたたみ／展開
4; 5-trisphosphate 5-phosphatase 2; Inositol phosphate 5' phosphatase 2; INPP 5H; INPP5H; KIAA0348; MGC44422; SJ2; Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 2; Synaptic inositol-1; Synaptojanin-2; Synaptojanin2; SYNJ 2; Synj2; SYNJ2_HUMAN;
免疫原
- O15056 SYNJ2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15056 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| Y61 | Phosphorylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| Y130 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| Y490 | Phosphorylation | P12931 (SRC) | Uniprot |
| S504 | Phosphorylation | Uniprot | |
| K515 | Ubiquitination | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| K781 | Ubiquitination | Uniprot | |
| S825 | Phosphorylation | Uniprot | |
| S838 | Phosphorylation | Uniprot | |
| T918 | Phosphorylation | Uniprot | |
| S921 | Phosphorylation | Uniprot | |
| T991 | Phosphorylation | Uniprot | |
| S994 | Phosphorylation | Uniprot | |
| K1078 | Ubiquitination | Uniprot | |
| S1095 | Phosphorylation | Uniprot | |
| S1097 | Phosphorylation | Uniprot | |
| S1122 | Phosphorylation | Uniprot | |
| S1124 | Phosphorylation | Uniprot | |
| Y1136 | Phosphorylation | Uniprot | |
| S1137 | Phosphorylation | Uniprot | |
| T1141 | Phosphorylation | Uniprot | |
| K1169 | Ubiquitination | Uniprot | |
| S1191 | Phosphorylation | Uniprot | |
| S1196 | Phosphorylation | Uniprot | |
| T1220 | Phosphorylation | Uniprot | |
| S1251 | Phosphorylation | Uniprot | |
| S1318 | Phosphorylation | Uniprot | |
| Y1411 | Phosphorylation | Uniprot | |
| K1432 | Ubiquitination | Uniprot | |
| S1433 | Phosphorylation | Uniprot | |
| S1434 | Phosphorylation | Uniprot | |
| S1439 | Phosphorylation | Uniprot | |
| T1441 | Phosphorylation | Uniprot | |
| S1443 | Phosphorylation | Uniprot | |
| T1496 | Phosphorylation | Uniprot |
研究背景
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Cytoplasm. Cell membrane. Membrane raft. Cell junction>Synapse>Presynapse. Cytoplasm>Cytoskeleton.
Note: Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340).
Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.
Belongs to the synaptojanin family.
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
研究領域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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