FYB Antibody - #DF7813
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7813, RRID:AB_2841264.
折りたたみ／展開
ADAP; Adhesion and degranulation promoting adaptor protein; FYB 120/130; Fyb; FYB-120/130; FYB_HUMAN; FYN binding protein; FYN T binding protein; FYN-binding protein; FYN-T-binding protein; p120/p130; PRO0823; SLAP 130; SLAP-130; SLAP130; SLP 76 associated phosphoprotein; SLP-76-associated phosphoprotein; SLP76 associated phosphoprotein;
免疫原
Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
- O15117 FYB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKYNTGGNPTEDVSVNSRPFRVTGPNSSSGIQARKNLFNNQGNASPPAGPSNVPKFGSPKPPVAVKPSSEEKPDKEPKPPFLKPTGAGQRFGTPASLTTRDPEAKVGFLKPVGPKPINLPKEDSKPTFPWPPGNKPSLHSVNQDHDLKPLGPKSGPTPPTSENEQKQAFPKLTGVKGKFMSASQDLEPKPLFPKPAFGQKPPLSTENSHEDESPMKNVSSSKGSPAPLGVRSKSGPLKPAREDSENKDHAGEISSLPFPGVVLKPAASRGGPGLSKNGEEKKEDRKIDAAKNTFQSKINQEELASGTPPARFPKAPSKLTVGGPWGQSQEKEKGDKNSATPKQKPLPPLFTLGPPPPKPNRPPNVDLTKFHKTSSGNSTSKGQTSYSTTSLPPPPPSHPASQPPLPASHPSQPPVPSLPPRNIKPPFDLKSPVNEDNQDGVTHSDGAGNLDEEQDSEGETYEDIEASKEREKKREKEEKKRLELEKKEQKEKEKKEQEIKKKFKLTGPIQVIHLAKACCDVKGGKNELSFKQGEQIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKLKKDSLGAPSRPIEDDQEVYDDVAEQDDISSHSQSGSGGIFPPPPDDDIYDGIEEEDADDGFPAPPKQLDMGDEVYDDVDTSDFPVSSAEMSQGTNVGKAKTEEKDLKKLKKQEKEEKDFRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15117 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Acetylation | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| T94 | Phosphorylation | Uniprot | |
| K111 | Acetylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K149 | Acetylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| T161 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K179 | Acetylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| K265 | Acetylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K298 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| T308 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| K334 | Acetylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| T374 | Phosphorylation | Uniprot | |
| T385 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| Y387 | Phosphorylation | Uniprot | |
| K425 | Acetylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| T461 | Phosphorylation | Uniprot | |
| Y462 | Phosphorylation | Uniprot | |
| K496 | Ubiquitination | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| K549 | Ubiquitination | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| Y559 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y561 | Phosphorylation | Uniprot | |
| Y571 | Phosphorylation | P06241 (FYN) | Uniprot |
| S573 | Phosphorylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| Y595 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y625 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y651 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y701 | Phosphorylation | Uniprot | |
| Y709 | Phosphorylation | Uniprot | |
| T711 | Phosphorylation | Uniprot | |
| K730 | Ubiquitination | Uniprot | |
| S734 | Phosphorylation | Uniprot | |
| K745 | Ubiquitination | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| Y755 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y757 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y762 | Phosphorylation | Uniprot | |
| Y771 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y780 | Phosphorylation | P06241 (FYN) | Uniprot |
研究背景
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).
T-cell receptor ligation leads to increased tyrosine phosphorylation.
Cytoplasm. Nucleus. Cell junction.
Note: Colocalizes with TMEM47 at cell-cell contacts in podocytes.
Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
Part of a complex consisting of SKAP2, FYB1 and PTPNS1 (By similarity). Part of a complex consisting of SKAP2, FYB1 and LILRB3 (By similarity). Part of a complex consisting of SKAP1, FYB1 and CLNK (By similarity). Interacts with CLNK (via its SH2 domain); this interaction allows SKAP1 and FYB1 to recruit FYN to the complex, thus promoting the phosphorylation of CLNK by FYN (By similarity). Interacts with FYN. Interacts with LCP2. Interacts with SKAP1. Interacts with SKAP2. Interacts with FASLG. Interacts with EVL. Interacts with TMEM47 (By similarity). Interacts with LCK.
研究領域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
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