CTNNBL1 Antibody - #DF7835
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7835, RRID:AB_2841275.
折りたたみ／展開
5730471K09Rik; Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Cadherin associated protein; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNN protein; CTNNBL 1; Ctnnbl1; dJ633O20.1; FLJ21108; NAP; Nuclear associated protein; nuclear protein NAP; Nuclear-associated protein; NYD SP19; OTTMUSP00000016933; P14; P14L; PP8304; RP5 1118M15.1; Testis development protein NYD SP19; Testis development protein NYD-SP19;
免疫原
Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.
- Q8WYA6 CTBL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDVGELLSYQPNRGTKRPRDDEEEEQKMRRKQTGTRERGRYREEEMTVVEEADDDKKRLLQIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEGAEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQKRILGLLENF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8WYA6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| R13 | Methylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| K56 | Acetylation | Uniprot | |
| R65 | Methylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| T398 | Phosphorylation | Uniprot | |
| T399 | Phosphorylation | Uniprot | |
| K429 | Ubiquitination | Uniprot | |
| K437 | Ubiquitination | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| R469 | Methylation | Uniprot | |
| T477 | Phosphorylation | Uniprot | |
| K527 | Acetylation | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| Y536 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot |
研究背景
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.
Nucleus.
Cytoplasm.
Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.
The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
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