APBB1IP Antibody - #DF7836
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7836, RRID:AB_2841276.
折りたたみ／展開
AB1IP; Amyloid beta A4 precursor protein binding family B member 1 interacting protein; Amyloid beta precursor protein binding family B member 1; APBB1 interacting protein 1; INAG1; OTTHUMP00000019344; PREL 1; PREL1; Proline rich EVH1 ligand 1; Proline rich protein 73; Rap1 GTP interacting adapter molecule; RAP1 interacting adaptor molecule; RARP 1; RARP1; Retinoic acid responsive proline rich protein 1;
免疫原
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
- Q7Z5R6 AB1IP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVLQEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKGTGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPPPPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQKKRGNVS
PTMs - Q7Z5R6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y45 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| Y274 | Phosphorylation | Uniprot | |
| Y331 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| Y340 | Phosphorylation | Uniprot | |
| Y341 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| Y380 | Phosphorylation | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| S526 | Phosphorylation | Uniprot | |
| T528 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| T534 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot |
研究背景
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Cell membrane>Peripheral membrane protein. Cell projection>Lamellipodium. Cell junction>Focal adhesion. Cytoplasm>Cytoskeleton.
Note: Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.
The two Pro-rich regions are required for the suppression of AP1 transcription activity.
Belongs to the MRL family.
研究領域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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