INPP4A Antibody - #DF7873
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7873, RRID:AB_2841301.
折りたたみ／展開
107kDa; 4-bisphosphate 4-phosphatase; 9630012D15; D130048C09Rik; Inositol polyphosphate 4 phosphatase type I 107kDa; Inositol polyphosphate 4 phosphatase type I; Inositol polyphosphate 4-phosphatase type I; INP4A_HUMAN; INPP4; Inpp4a; OTTHUMP00000203138; OTTHUMP00000203139; OTTHUMP00000203141; OTTHUMP00000225217; R74740; TVAS1; Type I inositol 3 4 bisphosphate 4 phosphatase; Type I inositol 3,4 bisphosphate 4 phosphatase; Type I inositol-3;
免疫原
Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
- Q96PE3 INP4A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96PE3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | Phosphorylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| R147 | Methylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| K321 | Methylation | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| Y355 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y427 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| S487 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| K745 | Ubiquitination | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| T942 | Phosphorylation | Uniprot | |
| Y951 | Phosphorylation | Uniprot | |
| S955 | Phosphorylation | Uniprot | |
| K959 | Ubiquitination | Uniprot | |
| K963 | Ubiquitination | Uniprot | |
| Y965 | Phosphorylation | Uniprot | |
| Y972 | Phosphorylation | Uniprot | |
| K974 | Ubiquitination | Uniprot |
研究背景
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction>Synapse>Postsynaptic density.
Note: Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275).
Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
Interacts with INPP5F.
Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
研究領域
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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