PARVA Antibody - #DF7874
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7874, RRID:AB_2841302.
折りたたみ／展開
Actopaxin; Alpha parvin; Alpha-parvin; Calponin like integrin linked kinase binding protein; Calponin-like integrin-linked kinase-binding protein; CH ILKBP; CH-ILKBP; FLJ10793; FLJ12254; Matrix remodelling associated 2; Matrix remodelling associated protein 2; Matrix-remodeling-associated protein 2; MXRA 2; MXRA2; PARV A; Parva; PARVA_HUMAN;
免疫原
A synthesized peptide derived from human PARVA, corresponding to a region within C-terminal amino acids.
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
- Q9NVD7 PARVA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
PTMs - Q9NVD7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| T16 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| K32 | Acetylation | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| T36 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| T167 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| Y362 | Phosphorylation | Uniprot |
研究背景
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Cell junction>Focal adhesion. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Constituent of focal adhesions. Associates with the actin cytoskeleton.
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
Interacts with TGFB1I1 (By similarity). Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with ARHGAP31. Interacts with the actin cytoskeleton.
Belongs to the parvin family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
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