PCYT1A Antibody - #DF7927
| 製品: | PCYT1A Antibody |
| カタログ: | DF7927 |
| タンパク質の説明: | Rabbit polyclonal antibody to PCYT1A |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 42 kDa; 42kD(Calculated). |
| ユニプロット: | P49585 |
| RRID: | AB_2841339 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7927, RRID:AB_2841339.
折りたたみ／展開
CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT; CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A;
免疫原
- P49585 PCY1A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49585 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K8 | Acetylation | Uniprot | |
| K8 | Sumoylation | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K57 | Acetylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| Y141 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| Y182 | Phosphorylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K266 | Sumoylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S315 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| S319 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| T342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| Y359 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot |
研究背景
Controls phosphatidylcholine synthesis.
The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).
Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Note: It can interconvert between an inactive cytosolic form and an active membrane-bound form.
Homodimer.
Belongs to the cytidylyltransferase family.
研究領域
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Metabolism > Metabolism of other amino acids > Phosphonate and phosphinate metabolism.
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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