MESDC2 Antibody - #DF7971
| 製品: | MESDC2 Antibody |
| カタログ: | DF7971 |
| タンパク質の説明: | Rabbit polyclonal antibody to MESDC2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Zebrafish, Bovine, Chicken |
| 分子量: | 26 kDa; 26kD(Calculated). |
| ユニプロット: | Q14696 |
| RRID: | AB_2841361 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7971, RRID:AB_2841361.
折りたたみ／展開
BOCA; KIAA0081; LDLR chaperone MESD; MESD; MESD_HUMAN; MESDC 2; mesdc2; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY REN 61; Renal carcinoma antigen NY-REN-61;
免疫原
- Q14696 MESD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASRWARKAVVLLCASDLLLLLLLLPPPGSCAAEGSPGTPDESTPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEENRAGNKREDL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14696 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y58 | Phosphorylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| S88 | O-Glycosylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| K95 | Methylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| T125 | Phosphorylation | Uniprot | |
| R179 | Methylation | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot |
研究背景
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).
Endoplasmic reticulum.
Note: Released from apoptotic cells and shed photoreceptor outer segments.
Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression (By similarity).
The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.
Belongs to the MESD family.
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