RGS9 Antibody - #DF7979
| 製品: | RGS9 Antibody |
| カタログ: | DF7979 |
| タンパク質の説明: | Rabbit polyclonal antibody to RGS9 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig |
| 分子量: | 55 kDa; 77kD(Calculated). |
| ユニプロット: | O75916 |
| RRID: | AB_2841366 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7979, RRID:AB_2841366.
折りたたみ／展開
PERRS; R9AP; Regulator of G protein signalling 9; Regulator of G-protein signaling 9; RGS9; RGS9_HUMAN; RGS9L;
免疫原
Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
- O75916 RGS9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQWIVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRYALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKVNQKQTVVAVKKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLAKAIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQPGQHMAPSPHLTVYTGTCMPPSPSSPFSSSCRSPRKPFASPSRFIRRPSTTICPSPIRVALESSSGLEQKGECSGSMAPRGPSVTESSEASLDTSWPRSRPRAPPKARMALSFSRFLRRGCLASPVFARLSPKCPAVSHGRVQPLGDVGQQLPRLKSKRVANFFQIKMDVPTGSGTCLMDSEDAGTGESGDRATEKEVICPWESL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75916 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S66 | Phosphorylation | Uniprot | |
| K141 | Acetylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| T563 | Phosphorylation | Uniprot | |
| S564 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot |
研究背景
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).
Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition (By similarity).
Membrane>Peripheral membrane protein.
Note: Isoform 3 is targeted to the membrane via its interaction with RGS9BP.
Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP. Interacts with PDE6G and GNAT1.
In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.
研究領域
· Human Diseases > Substance dependence > Cocaine addiction.
· Organismal Systems > Sensory system > Phototransduction.
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