FSCN1 Antibody - #DF7988
| 製品: | FSCN1 Antibody |
| カタログ: | DF7988 |
| タンパク質の説明: | Rabbit polyclonal antibody to FSCN1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 54 kDa; 55kD(Calculated). |
| ユニプロット: | Q16658 |
| RRID: | AB_2841372 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7988, RRID:AB_2841372.
折りたたみ／展開
55 kDa actin bundling protein; 55 kDa actin-bundling protein; Actin bundling protein; actin bundling protein, 55-KD; FAN 1; FAN1; Fascin 1; Fascin actin bundling protein 1; Fascin; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin, sea urchin, homolog of, 1; Fascin1; FLJ38511; FSCN 1; FSCN1; FSCN1_HUMAN; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like (fascin homolog sea urchin); Singed like protein; Singed, drosophila, homolog of; Singed-like protein; SNL; Strongylocentrotus purpuratus;
免疫原
- Q16658 FSCN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16658 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Acetylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | P17252 (PRKCA) , Q05655 (PRKCD) | Uniprot |
| K41 | Acetylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K74 | Acetylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| C80 | S-Nitrosylation | Uniprot | |
| R118 | Methylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| R217 | Methylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K250 | Acetylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K304 | Acetylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| Y314 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| K353 | Methylation | Uniprot | |
| K353 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| C397 | S-Nitrosylation | Uniprot | |
| K399 | Sumoylation | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| T403 | Phosphorylation | Uniprot | |
| Y411 | Phosphorylation | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| Y458 | Phosphorylation | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| K471 | Acetylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| T484 | Phosphorylation | Uniprot |
研究背景
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF.
Cytoplasm>Cytosol. Cytoplasm>Cell cortex. Cytoplasm>Cytoskeleton. Cytoplasm>Cytoskeleton>Stress fiber. Cell projection>Filopodium. Cell projection>Invadopodium. Cell projection>Microvillus. Cell junction.
Note: Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Ubiquitous.
Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development (By similarity). Interacts with NGFR (By similarity). Associates with CTNNB1 (By similarity). Interacts with PLXNB3.
Composed of four fascin beta-trefoil domains.
Belongs to the fascin family.
研究領域
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
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