SEMA4D Antibody - #DF8058
| 製品: | SEMA4D Antibody |
| カタログ: | DF8058 |
| タンパク質の説明: | Rabbit polyclonal antibody to SEMA4D |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Pig, Sheep, Rabbit, Dog |
| 分子量: | 96 kDa; 96kD(Calculated). |
| ユニプロット: | Q92854 |
| RRID: | AB_2841414 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8058, RRID:AB_2841414.
折りたたみ／展開
A8; BB 18; BB18; CD 100; CD100; CD100 antigen; Coll 4; COLL4; Collapsin 4; Collapsin4; GR3; Leukocyte activation antigen CD100; M sema G; MSEMA; SEM4D_HUMAN; Sema 4d; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4D; Sema H; SEMA J; Sema4d; Semacl 2; Semacl2; SemaH; SEMAJ; Semaphorin 4D; Semaphorin C like 2; Semaphorin H; Semaphorin J; Semaphorin-4D; Semaphorin4D; SemaphorinJ; Semcl 2; Semcl2;
免疫原
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
- Q92854 SEM4D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92854 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| N49 | N-Glycosylation | Uniprot | |
| N77 | N-Glycosylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| N139 | N-Glycosylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| N191 | N-Glycosylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K276 | Acetylation | Uniprot | |
| N329 | N-Glycosylation | Uniprot | |
| N379 | N-Glycosylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| N419 | N-Glycosylation | Uniprot | |
| K505 | Ubiquitination | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| Y561 | Phosphorylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| T657 | O-Glycosylation | Uniprot | |
| T663 | O-Glycosylation | Uniprot | |
| S666 | O-Glycosylation | Uniprot | |
| T670 | O-Glycosylation | Uniprot | |
| T716 | O-Glycosylation | Uniprot | |
| S722 | O-Glycosylation | Uniprot | |
| Y727 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| K790 | Ubiquitination | Uniprot | |
| S798 | Phosphorylation | Uniprot | |
| K808 | Ubiquitination | Uniprot | |
| Y815 | Phosphorylation | Uniprot | |
| T817 | Phosphorylation | Uniprot | |
| K825 | Ubiquitination | Uniprot | |
| S833 | Phosphorylation | Uniprot | |
| S840 | Phosphorylation | Uniprot | |
| S857 | Phosphorylation | Uniprot |
研究背景
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.
Cell membrane>Single-pass type I membrane protein.
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Homodimer. Interacts with PLXNB2 (By similarity). Interacts with PLXNB1.
Belongs to the semaphorin family.
研究領域
· Organismal Systems > Development > Axon guidance. (View pathway)
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