PTP4A2 Antibody - #DF8076
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8076, RRID:AB_2841430.
折りたたみ／展開
BM 008; EC 3.1.3.48; HH 13; HH13; HH7 2; HU PP 1; HUPP 1; HUPP1; OV 1; OV1; phosphatase of regenerating liver 2; PRL 2; PRL2; Protein tyrosine phosphatase 4a2; protein tyrosine phosphatase IVA; protein tyrosine phosphatase IVA2; Protein tyrosine phosphatase of regenerating liver 2; protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase type IVA member 2 isoform 1; protein tyrosine phosphatase type IVA, member 2; PTP (CAAXII); ptp IV1a; ptp IV1b; PTP4A; PTPCAAX2; TP4A2_HUMAN;
免疫原
Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
- Q12974 TP4A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q12974 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y11 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot |
研究背景
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
Cell membrane. Early endosome. Cytoplasm.
Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.
Belongs to the protein-tyrosine phosphatase family.
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