STAMBP Antibody - #DF8083
| 製品: | STAMBP Antibody |
| カタログ: | DF8083 |
| タンパク質の説明: | Rabbit polyclonal antibody to STAMBP |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Xenopus |
| 分子量: | 50 kDa; 48kD(Calculated). |
| ユニプロット: | O95630 |
| RRID: | AB_2841436 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8083, RRID:AB_2841436.
折りたたみ／展開
AMSH; Associated molecule with the SH3 domain of STAM; Endosome associated ubiquitin isopeptidase; Endosome-associated ubiquitin isopeptidase; MGC126516; MGC126518; MICCAP; STABP_HUMAN; STAM binding protein; STAM-binding protein; Stambp;
免疫原
- O95630 STABP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95630 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K88 | Acetylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K102 | Sumoylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| K153 | Acetylation | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| R255 | Methylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| R424 | Methylation | Uniprot |
研究背景
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Phosphorylated after BMP type I receptor activation.
Ubiquitinated by SMURF2 in the presence of RNF11.
Nucleus. Membrane>Peripheral membrane protein. Cytoplasm. Early endosome.
Ubiquitously expressed.
Interacts with STAM. Interacts with SMAD6 and SMAD7. Interacts with CHMP3; the interaction appears to relieve the autoinhibition of CHMP3. Interacts with SMURF2 and RNF11; this interaction promotes ubiquitination.
The JAMM motif is essential for the protease activity.
Belongs to the peptidase M67C family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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