FNTA Antibody - #DF8125
| 製品: | FNTA Antibody |
| カタログ: | DF8125 |
| タンパク質の説明: | Rabbit polyclonal antibody to FNTA |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 44 kDa; 44kD(Calculated). |
| ユニプロット: | P49354 |
| RRID: | AB_2841463 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8125, RRID:AB_2841463.
折りたたみ／展開
CAAX farnesyltransferase alpha subunit; CAAX farnesyltransferase subunit alpha; EC 2.5.1.58; EC 2.5.1.59; Farnesyl protein transferase alpha subunit; Farnesyltransferase CAAX box alpha; Farnesyltransferase, CAAX box, alpha; Fnta; FNTA_HUMAN; FPTA; FTase alpha; FTase-alpha; GGTase I alpha; GGTase-I-alpha; MGC99680; OTTHUMP00000229206; OTTHUMP00000229262; PGGT1A; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Protein prenyltransferase alpha subunit repeat containing 2; PTAR2; Ras proteins prenyltransferase alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha;
免疫原
- P49354 FNTA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P49354 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| Y92 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| T248 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| R253 | Methylation | Uniprot | |
| R287 | Methylation | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| T350 | Phosphorylation | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| S373 | Phosphorylation | Uniprot | |
| T375 | Phosphorylation | Uniprot |
研究背景
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).
Belongs to the protein prenyltransferase subunit alpha family.
研究領域
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
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