OXT Antibody - #DF8139

(2)  
製品: OXT Antibody
カタログ: DF8139
タンパク質の説明: Rabbit polyclonal antibody to OXT
アプリケーション: WB IF/ICC
反応性: Human
予測: Pig, Bovine, Horse, Sheep, Dog, Chicken
分子量: 12kDa; 13kD(Calculated).
ユニプロット: P01178
RRID: AB_2841474

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(86%)
クローナリティ:
Polyclonal
特異性:
OXT Antibody detects endogenous levels of total OXT.
RRID:
AB_2841474
引用形式: Affinity Biosciences Cat# DF8139, RRID:AB_2841474.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

MGC126890; MGC126892; Neurophysin 1; Neurophysin I; Ocytocin; OT; OT NPI; OXT; Oxytocin Neurophysin preproprotein; Oxytocin prepro (neurophysin I); Oxytocin prepropeptide; Oxytocin-neurophysin 1;

免疫原

免疫原:
Uniprot:

P01178(NEU1_HUMAN) >>Visit HPA database.

遺伝子(ID):
OXT(5020)
タンパク質配列:
MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
86
Xenopus
71
Zebrafish
71
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR).

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Interacts with oxytocin receptor (Ki=1.5 nM). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM) and V2R/AVPR2 receptors (Ki=823 nM).

タンパク質ファミリー:

Belongs to the vasopressin/oxytocin family.

研究領域

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

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