NRG3 Antibody - #DF8144
| 製品: | NRG3 Antibody |
| カタログ: | DF8144 |
| タンパク質の説明: | Rabbit polyclonal antibody to NRG3 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Rabbit, Dog |
| 分子量: | 56 kDa; 78kD(Calculated). |
| ユニプロット: | P56975 |
| RRID: | AB_2841476 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8144, RRID:AB_2841476.
折りたたみ／展開
HRG3; Neuregulin 3; Neuregulin 3 like polypeptide; Neuregulin-3; Neuregulin3; NRG-3; Nrg3; NRG3_HUMAN; Pro neuregulin 3; pro NRG3; Pro-NRG3;
免疫原
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
- P56975 NRG3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P56975 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S116 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| T276 | O-Glycosylation | Uniprot | |
| T277 | O-Glycosylation | Uniprot | |
| T278 | O-Glycosylation | Uniprot | |
| S280 | O-Glycosylation | Uniprot | |
| T281 | O-Glycosylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| T609 | Phosphorylation | Uniprot |
研究背景
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
Cell membrane>Single-pass type I membrane protein.
Note: Does not seem to be active.
Secreted.
Cell membrane>Single-pass type I membrane protein.
Note: Isoform 3 is also proteolytically released as a soluble form.
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Interacts with ERBB4.
The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
ERBB receptor binding is elicited entirely by the EGF-like domain.
Belongs to the neuregulin family.
研究領域
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
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