UBE2L6 Antibody - #DF8152

(2)  
製品: UBE2L6 Antibody
カタログ: DF8152
タンパク質の説明: Rabbit polyclonal antibody to UBE2L6
アプリケーション: WB IF/ICC
反応性: Human
分子量: 18 kDa; 18kD(Calculated).
ユニプロット: O14933
RRID: AB_2841480

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
UBE2L6 Antibody detects endogenous levels of total UBE2L6.
RRID:
AB_2841480
引用形式: Affinity Biosciences Cat# DF8152, RRID:AB_2841480.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

MGC40331; Retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG B; RIG-B; UB2L6_HUMAN; UBCH 8; UbcH8; UBE2L6; Ubiquitin carrier protein; Ubiquitin carrier protein L6; Ubiquitin conjugating enzyme E2L 6; Ubiquitin protein ligase; Ubiquitin protein ligase L6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15 conjugating enzyme E2 L6; Ubiquitin/ISG15-conjugating enzyme E2 L6;

免疫原

免疫原:
Uniprot:

O14933(UB2L6_HUMAN) >>Visit HPA database.

遺伝子(ID):
UBE2L6(9246)
発現特異性:
O14933 UB2L6_HUMAN:

Present in natural killer cells (at protein level).

タンパク質配列:
MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS

PTMs - O14933 基板として

Site PTM Type Enzyme
K9 Ubiquitination
K17 Ubiquitination
S26 Phosphorylation
K96 Ubiquitination
K138 Acetylation
K138 Ubiquitination
S153 Phosphorylation

研究背景

機能:

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

PTMs:

ISGylated.

組織特異性:

Present in natural killer cells (at protein level).

サブユニット構造:

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).

タンパク質ファミリー:

Belongs to the ubiquitin-conjugating enzyme family.

研究領域

· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

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