alpha 2 Macroglobulin/A2M Antibody - #DF8174
| 製品: | alpha 2 Macroglobulin/A2M Antibody |
| カタログ: | DF8174 |
| タンパク質の説明: | Rabbit polyclonal antibody to alpha 2 Macroglobulin/A2M |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 180 kDa; 163kD(Calculated). |
| ユニプロット: | P01023 |
| RRID: | AB_2841493 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8174, RRID:AB_2841493.
折りたたみ／展開
A2m; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7;
免疫原
- P01023 A2MG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA
PTMs - P01023 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N55 | N-Glycosylation | Uniprot | |
| N70 | N-Glycosylation | Uniprot | |
| N247 | N-Glycosylation | Uniprot | |
| T346 | Phosphorylation | Uniprot | |
| N396 | N-Glycosylation | Uniprot | |
| N410 | N-Glycosylation | Uniprot | |
| Y497 | Phosphorylation | Uniprot | |
| T679 | Phosphorylation | Uniprot | |
| Y695 | Phosphorylation | Uniprot | |
| Y708 | Phosphorylation | Uniprot | |
| S710 | Phosphorylation | Uniprot | |
| Y817 | Phosphorylation | Uniprot | |
| K820 | Acetylation | Uniprot | |
| T861 | Phosphorylation | Uniprot | |
| N869 | N-Glycosylation | Uniprot | |
| T898 | Phosphorylation | Uniprot | |
| N991 | N-Glycosylation | Uniprot | |
| Y1007 | Phosphorylation | Uniprot | |
| Y1012 | Phosphorylation | Uniprot | |
| Y1021 | Phosphorylation | Uniprot | |
| Y1025 | Phosphorylation | Uniprot | |
| K1147 | Acetylation | Uniprot | |
| K1162 | Acetylation | Uniprot | |
| K1164 | Acetylation | Uniprot | |
| K1168 | Acetylation | Uniprot | |
| S1387 | Phosphorylation | Uniprot | |
| T1395 | Phosphorylation | Uniprot | |
| N1424 | N-Glycosylation | Uniprot |
研究背景
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Secreted.
Secreted in plasma.
Homotetramer; disulfide-linked.
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
研究領域
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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