MUNC-18a Antibody - #DF8202
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8202, RRID:AB_2841510.
折りたたみ／展開
FLJ37475; Munc 18 1; Munc 18a; MUNC18 1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STXB1_HUMAN; STXBP1; Syntaxin binding protein 1; Syntaxin-binding protein 1; Unc 18 homolog; Unc 18A; Unc-18A; Unc18 1; UNC18; Unc18-1;
免疫原
- P61764 STXB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P61764 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K7 | Ubiquitination | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| K321 | Methylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| T479 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| T489 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| Y531 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot |
研究背景
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Brain and spinal cord. Highly enriched in axons.
Interacts with SYTL4 (By similarity). Interacts with STX1A. Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation. Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity).
Belongs to the STXBP/unc-18/SEC1 family.
研究領域
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
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