Factor V Antibody - #DF8265
| 製品: | Factor V Antibody |
| カタログ: | DF8265 |
| タンパク質の説明: | Rabbit polyclonal antibody to Factor V |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 250 kDa; 252kD(Calculated). |
| ユニプロット: | P12259 |
| RRID: | AB_2841554 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8265, RRID:AB_2841554.
折りたたみ／展開
Activated protein C cofactor; APC cofactor; coagulation factor V (proaccelerin, labile factor); Coagulation factor V; coagulation factor V jinjiang A2 domain; Coagulation factor V light chain; F5; FA5_HUMAN; Factor V Leiden; FactorV; FVL; Labile factor; PCCF; Proaccelerin; proaccelerin, labile factor; Protein C cofactor; RPRGL1; THPH2;
免疫原
- P12259 FA5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P12259 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S123 | Phosphorylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| Y128 | Phosphorylation | Uniprot | |
| T132 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| N297 | N-Glycosylation | Uniprot | |
| Y323 | Phosphorylation | Uniprot | |
| N460 | N-Glycosylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| T640 | Phosphorylation | Uniprot | |
| S692 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| Y693 | Phosphorylation | Uniprot | |
| T706 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T804 | O-Glycosylation | Uniprot | |
| T805 | O-Glycosylation | Uniprot | |
| N821 | N-Glycosylation | Uniprot | |
| S859 | Phosphorylation | Uniprot | |
| K864 | Acetylation | Uniprot | |
| K866 | Acetylation | Uniprot | |
| S895 | Phosphorylation | Uniprot | |
| T898 | Phosphorylation | Uniprot | |
| S937 | Phosphorylation | Uniprot | |
| S955 | Phosphorylation | Uniprot | |
| N977 | N-Glycosylation | Uniprot | |
| T1038 | Phosphorylation | Uniprot | |
| T1047 | Phosphorylation | Uniprot | |
| S1053 | Phosphorylation | Uniprot | |
| Y1056 | Phosphorylation | Uniprot | |
| T1058 | Phosphorylation | Uniprot | |
| S1148 | Phosphorylation | Uniprot | |
| S1150 | Phosphorylation | Uniprot | |
| N1559 | N-Glycosylation | Uniprot | |
| Y1623 | Phosphorylation | Uniprot | |
| S1626 | Phosphorylation | Uniprot | |
| T1627 | Phosphorylation | Uniprot | |
| T1629 | Phosphorylation | Uniprot | |
| S1676 | Phosphorylation | Uniprot | |
| T1685 | Phosphorylation | Uniprot | |
| S1690 | Phosphorylation | Uniprot | |
| Y1783 | Phosphorylation | Uniprot | |
| Y1784 | Phosphorylation | Uniprot | |
| S2011 | Phosphorylation | Uniprot | |
| T2026 | Phosphorylation | Uniprot | |
| Y2149 | Phosphorylation | Uniprot | |
| S2158 | Phosphorylation | Uniprot | |
| S2198 | Phosphorylation | Uniprot | |
| S2211 | Phosphorylation | Uniprot |
研究背景
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Activated protein C inactivates factor V and factor Va by proteolytic degradation.
Phosphorylated by FAM20C in the extracellular medium.
Secreted.
Plasma.
Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5.
Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
Belongs to the multicopper oxidase family.
研究領域
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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